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Comments about this book Report This Book Reason: The content or quality of The Loop may be out of date, inaccurate, or incomplete. For a more accurate and complete review, see below. Author Publisher Review Tanya Royce from San Mateo, CA on 16. Jun. 2010: I read ‘Making the Leap’ in ‘Making the Leap: Adventures in Agile Software Development’ when it was first published. I found it to be an excellent read on the subject. Its a bit dated now, but its still an interesting read. Leslie Harrison from Hemet, CA on 13. May 2010: The Loop is a very interesting story and would be a perfect addition for a History class.Regulation of the PTEN tumor suppressor by the EGFR. Altered regulation of protein phosphatases is a consistent finding in human tumors. Here, we report that in breast cancer cell lines, the epidermal growth factor receptor (EGFR) pathway selectively upregulates the PTEN phosphatase. These cells express low basal levels of PTEN, and ectopic overexpression of PTEN reduces the growth and survival of PTEN-null cells. Conversely, inhibition of EGFR signaling in EGFR-overexpressing cells results in reduced PTEN levels and increased apoptosis. Inhibition of AKT kinase activity mimics the effects of inhibition of EGFR, further supporting a role for the PI3K-AKT pathway in PTEN downregulation. We conclude that regulation of PTEN by EGFR is a major determinant of cell growth and survival in breast cancer cells.Quilting. Improving my life. Menu Category Archives: Sewing Recently I saw a cute quilt on Pinterest. I had no idea that summer wasn’t over until the sun actually went down. (Yes, I use a compass…and my calendar.) When I saw the pattern, I knew I could make it in the style of the 1980s – bright colors and geometric patterns. The pattern’s body is a 6×6 quilt with a 10″ sashing. The pattern’s instructions call for five to six pieces of fabric but I made the quilt with six and it came out great. I followed the pattern and used a different block for the quilt. If you look closely, there are a lot