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Of 160 consecutive patients undergoing curative resection of the rectum for primary adenocarcinoma, 6 (3.8%) had metachronous cancers in the sigmoid colon or rectum. Nine patients with synchronous cancers (mean age 71 years) underwent abdominoperineal excision. Ten patients with synchronous cancers (mean age 70 years) underwent abdominoperineal excision followed by colonic resection and Hartmann procedure for carcinoma of the left colon. Four patients with synchronous cancers (mean age 73 years) underwent Hartmann’s procedure for advanced colorectal carcinoma. The mean interval between primary rectal cancer and second rectal cancer was 12.8 years. Only 3 patients with metachronous cancers presented symptoms. Radiologic detection of rectal tumor was more frequent in patients with metachronous rectal cancer (P less than 0.01). The 5-year disease-free survival in patients with metachronous rectal cancer after abdominoperineal excision (6 of 12 patients) was significantly worse than in those without metachronous rectal cancer (12 of 47 patients; P less than 0.025). We conclude that patients with recurrent or metachronous colorectal carcinoma may be at high risk for recurrence. Therefore, more intensive treatment or surveillance should be considered for patients at this high-risk stage./*
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You are commenting using your Apple ID. Comment on this story: com/ 5GtNZ5JPzwDpFerg.Effect of boundary conditions on water-melon mesophase.
The two-dimensional electron density and transverse electric field distribution of the water-melon mesophase are calculated using an exactly solvable model of a one-component gas and an effective Landau-Ginzburg theory. The unique phase boundary consists of a hexagonal phase and two triangular lattices. An optimized Landau-Ginzburg potential leads to the same phases with a good agreement, thus validating the Landau-Ginzburg theory. The hexagonal-to-square phase transition occurs at a temperature where the temperature of the square-to-triangular phase transition becomes zero. The phase boundary of the triangular-to-triangular transition is found to be dependent on the system size. In the extreme case where the system is a square, the discontinuity in the phase boundary disappears.This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject’s principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of the ICBG is to conduct clinical, translational, and population research relevant to the prevention, diagnosis, and treatment of neuropsychiatric conditions. All such work must be conducted according to NIH guidelines and must conform to the Protection of Human Subjects regulations governing the conduct of research with human subjects. The target population includes all of the 2.4 million people living in the 15 area census tracts in Omaha, Nebraska and environs. The target population is also all of the participants in all large studies currently being conducted in Omaha, Nebraska. We will also conduct research on all the approximately 23,000 students (twin and nontwin) currently enrolled in Omaha school districts. In the current ICBG cycle, we will conduct pilot work in genetics research in this population. Specifically,