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Updated on 2019-03-29. Published on 2019-03-26. Cerberus v 1.5 Cracked For Android. 1 Like.
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Add more devices from your phone to your account and get Cerberus Lite to save them all.Clinical relevance of genetic variants in androgen and estrogen metabolism genes in prostate cancer: a systematic review and meta-analysis.
In the past few years, several studies have explored the clinical relevance of genetic variants in androgen and estrogen metabolism genes in prostate cancer (PCa), which may predict the tumor’s clinical outcome. However, the reported genetic associations with clinical outcomes are still controversial and inconclusive. Thus, we performed a systematic review and meta-analysis of studies to provide a quantitative estimate of the relevant associations. We searched PubMed and the Cochrane Library from their inception to May 1, 2016. Our search was based on a set of detailed search terms. We extracted data from the included studies using a standardized data extraction form. Using a random-effect model, pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each polymorphism. Sensitivity analysis, cumulative meta-analysis, and publication bias analysis were performed to evaluate the heterogeneity and potential bias. Finally, we summarized the evidence quality according to the GRADE approach. A total of 31 studies (11,889 cases and 10,820 controls) were included in this meta-analysis. Overall, no significant differences were observed in the comparisons of homozygous mutant genotypes and recessive genotypes of CYP19A1 (TT vs CC: OR = 0.94; 95% CI = 0.74-1.19; TT vs CC/CT: OR = 0.99; 95% CI = 0.87-1.13), ESR1 (TA/AA: OR = 1.02; 95
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