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Windows XP SP2 (SP3), Windows Vista or Windows 7 (both 32 and 64 bit), any edition.In a separate study, the researchers looked at 3,500 women in the Rotterdam section of the European Prospective Investigation into Cancer and Nutrition (EPIC), a study that followed 20,000 women for up to 13 years. They found that after accounting for other factors, like age, being overweight or underweight, and whether or not they took certain cancer drugs, the risk of breast cancer was 30 percent higher for women with the T allele compared to those with the C allele. For postmenopausal breast cancer, that risk was even higher at 60 percent higher.
“All the risk factors that we have accounted for in this study still add up to a 30 percent increase in risk,” said Dr. Janet Spinelli, the study’s senior author. “The overall risk of breast cancer is still higher for those with the TT genotype.”
The researchers emphasize that the T allele is not the same as having a higher-than-average genetic risk. “The T allele is a genetic risk factor, but it is just one piece of a huge jigsaw puzzle,” Dr. Spinelli said.
The genes in question are on a different chromosome than most breast cancer genes, and the researchers caution that if women with the T allele take steps to prevent breast cancer, it does not mean they are guaranteed to avoid the disease.
Still, Dr. Spinelli said, “This study shows us that the T allele has a moderate impact on risk, and that could be really useful for clinicians to know so that they can convey this information to patients.”
Dr. Spinelli also said that it would be interesting to look at whether there was a link between breast cancer and other cancers that are correlated with obesity, like endometrial cancer. She said that it would also be useful to look at whether obesity might be a risk factor for women with inherited mutations like the BRCA1 and BRCA2 genes, which make women especially prone to the development of breast cancer.
Dr. Spinelli said that the study should not affect women’s decisions about whether to have children, since women with the T allele have a roughly 30 percent higher risk of breast cancer